ea0029p533 | Diabetes | ICEECE2012
Buhl M.
, Bosnjak E.
, Gjedsted J.
, Nielsen R.
, Jessen N.
, Hafstrom T.
, Vestergaard E.
, Tonnesen E.
, Moller N.
Introduction: In humans bacterial lipopolysaccharide (LPS/endotoxin) causes chronic low-grade and acute inflammatory responses, which decrease insulin sensitivity and may lead to chronic type 2 diabetes and acute stress diabetes. Systemic LPS invariably generates cytokine release, which triggers release of anti-insulin stress hormones and it is not known whether insulin resistance is secondary to stress hormones or LPS per se. Our study was designed to test whether local place...